NOS3 and endothelial dysfunction: SARS-COV-2-mediated release of cytokines such as IL-6, or increased levels of the endogenous competitive inhibitor of endothelial nitric oxide synthase, asymmetrical dimethylarginine (ADMA), may also promotes endothelial dysfunction and vascular smooth muscle cell proliferation and, thus, contribute to SARS-COV-2-associated PH (Hannemann et al., 2021; Jones and Hunter, 2021).