SARS-COV-2-mediated release of cytokines such as IL-6, or increased levels of the endogenous competitive inhibitor of endothelial nitric oxide synthase, asymmetrical dimethylarginine (ADMA), may also promotes endothelial dysfunction and vascular smooth muscle cell proliferation and, thus, contribute to SARS-COV-2-associated PH. This evidence concerns the gene IL6 and endothelial dysfunction.