MAP2K7 and pulmonary arterial hypertension: Suzuki and colleagues demonstrated that the SARS-COV-2 spike protein may trigger cell growth signaling via fast activation of the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway in human pulmonary vascular smooth muscle and endothelial cells, which raises the intriguing question of whether the spike protein predisposes subjects infected with SARS-COV-2 to develop PAH in the future, regardless of the severity of COVID-19 (Suzuki et al., 2021).