The animal model of IgA nephropathy was established by bovine serum albumin (BSA) + lipopolysaccharide (LPS) + carbon tetrachloride (CCL4) in 22 studies [10, 11, 13–22, 24–26, 32–39], and BSA + staphylococcal enterotoxin-B (SEB) in 8 studies [12, 23, 27–31, 40]. This evidence concerns the gene SETBP1 and IgA glomerulonephritis.