HNRNPD and Sepsis: Importantly, AUF-1 is found to decay mRNA of sphingosine kinase1 (Sobue et al., 2008), which produces Spingosine-1-phospahte (S1P), a biomarker of sepsis (Hasan and Karst, 1989) and other inflammatory diseases (Suh and Saba, 2015).