The most common Antibody (Ab)-mediated disorders of the central nervous system (CNS) are aquaporin-4 antibody neuromyelitis optica spectrum disorders (AQP4+NMOSD), myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and autoimmune encephalitis (AE). Here, AQP4 is linked to acrodermatitis enteropathica.