Content for this paper was gathered by PubMed literature review for articles published between 2012 and 2022 with the following search terms: “aquaporin 4,” “neuromyelitis optica spectrum disorder,” “myelin- oligodendrocyte glycoprotein antibody-associated disease,” “autoimmune encephalitis,” “NMDAr,” “LGI1,” “CASPR2,” “fertility,” “partum,” “delivery,” “postpartum,” “pregnancy,” “breastfeeding,” “fetus,” “gestation,” and “treatment.” Here, AQP4 is linked to neuromyelitis optica.