Also, Univariate Cox analysis showed that 10 of 26 writers (CSTF2, CPSF4, METTL3, NUDT21, ADARB2, PABPN1, CPSF1, VIRMA, METTL14 and CFI) were independent prognostic factors in PC patients (Figure S3B). Here, METTL3 is linked to pachyonychia congenita.