Also, Univariate Cox analysis showed that 10 of 26 writers (CSTF2, CPSF4, METTL3, NUDT21, ADARB2, PABPN1, CPSF1, VIRMA, METTL14 and CFI) were independent prognostic factors in PC patients (Figure S3B). The gene discussed is CPSF4; the disease is pachyonychia congenita.