At last, a 10-DEGs (including CXCL9, GREM1, INHBA, SEMA3C, C1S, PGGHG, PABPC1L, BRICD5, PCSK1N and C4orf48) based model named WM_Score model was established, and PC patients were divided into WM_Score_high (WM_high) and WM_Score_low (WM_low) groups based on the median WM_Score. The gene discussed is SEMA3C; the disease is pachyonychia congenita.