Podocytes are a type of terminally differentiated epithelial cell that play an important role in inhibiting the leakage of protein in a positive manner (21); Pyroptosis mediated by the nucleotide oligomerization domain-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome is a new type of cell death that serves as a key pathological factor contributing to accelerated DKD injury (22, 23). This evidence concerns the gene NLRP3 and diabetic kidney disease.