M1 macrophage-derived exosomal lncRNA-HOTTIP and M2 macrophage-derived exosomal lncRNA-AFAP1-AS1 affect tumor metastasis by modulating the miR-26a/ATF2 axis and miR-19a/b-3p/TLR5/NF-κB signaling pathway, respectively, which provides a potential strategy for tumor immunotherapy (125, 126). Here, HOTTIP is linked to neoplasm.