CD274 and neoplasm: Moreover, lncRNA-SNHG14 is upregulated in diffuse large B-cell lymphoma, and the SNHG14/miR-5590-3p/ZEB1 axis can also regulate the PD-1/PD-L1 checkpoint to promote the progression and immune evasion of tumor cells, which indicates that targeting SNHG14 may be a potential target to improve the immunotherapeutic effect in tumors (12).