The direct interaction of lncRNA-PURPL (p53 upregulated regulator of p53 levels) with mTOR and ULK1 promotes the phosphorylation of ULK1 at Ser757 to inhibit autophagy and reduce cell death, while the inhibition of PURPL induces autophagy and inhibits melanoma progression by regulating the AMPK signaling pathway and leading to the phosphorylation of ULK1 at Ser555 and Ser317 (72). Here, PURPL is linked to melanoma.