Additionally, the expression of lncRNA-SNHG15 can be modulated by palbociclib and alleviate temozolomide resistance by regulating the CDK6/miR-627 pathway and reducing M2 polarization of glioma-associated microglia, providing evidence for treatment with temozolomide resistance with the use of CDK6 inhibitors (10). The gene discussed is CDK6; the disease is central nervous system cancer.