In the cytoplasm, lncRNA-IFITM4P directly binds to SASH1 and phosphorylates TAK1 (Thr187) to increase the phosphorylation of NF-κB (ser536), thus inducing the expression of PD-L1, inhibiting the activation of the immune system and increasing the immune escape of tumor cells. The gene discussed is NFKB1; the disease is neoplasm.