LncRNA-INCR1 (interferon-stimulated noncoding RNA 1) also transcribed from the PD-L1 locus promotes the expression of PD-L1, JAK2, and several IFNγ-related genes, which can regulate the sensitivity of tumor cells to cytotoxic T-cell-mediated killing and affect the therapeutic effect of CAR T-cell therapy (115). This evidence concerns the gene CD274 and neoplasm.