In a consecutive series of patients with first optimally treated STEMI and prospectively followed-up by echocardiography, we found that: (1) in the sub-acute phase of STEMI iLS, rLS, and bLS are independent of extent of CAD and are associated to LVEF; (2) NT-proBNP level at admission is an independent predictor of rLS; (3) despite an overall improvement of contractile function over time, patients with more impaired rLS at baseline show worse LV morphological and functional indexes also at follow-up. Here, NPPB is linked to coronary artery disorder.