EGFR may be transactivated by GPCRs for regulating DNA expression and the cell cycle (Daub et al., 1996; Kalmes et al., 2000; Shah et al., 2003; Alsahafi et al., 2020), as well as by LPA and S1P for mediating cancer pathophysiology (Gschwind et al., 2002; Deng et al., 2004; Sukocheva et al., 2006; Tveteraas et al., 2016). This evidence concerns the gene EGFR and cancer.