SHBG and chronic kidney disease: The positive association between higher SHBG levels and eGFR at follow-up in men with SHBG levels above the mean, together with the tendency for an inverse association between SHBG and incident CKD was partially consistent to findings from an observational study (9) and an MR study that reported significant associations between genetically-predicted higher SHBG concentrations and lower CKD risk, independent of T (15).