Bone turnover markers (BTMs), including osteocalcin, C-terminal telopeptide (CTX), and N-terminal pro-peptide of type-I procollagen (PINP), are used as indicators of bone formation and bone loss, as a means of diagnosing secondary osteoporosis, or assessing the effectiveness of osteoporosis treatment (4). Here, BGLAP is linked to osteoporosis.