GSTK1 and Alzheimer disease: These results indicated that suppression of selective VGCCs could enhance oxidative stress resistance via upregulation of clhm-1, unc-68, and ncx-1 to strengthen HPGDS and skn-1, and then GST, further inhibiting Aβ1–42 aggregation, to ameliorate neuronal degeneration and dysfunction in AD worms (the graphical mechanism illustrated in Figure 8).