Extrapulmonary TB without evidence of pulmonary TBSevere illness or any condition causing the adolescent to be clinically unstable or require intensive care treatmentPregnancy or breast feeding (due to exposure to ionising radiation)Diabetes mellitus (due to the potential confounding effects of hyperglycaemia and insulin levels on 18F-FDG uptake on PET/CT)Participants declining HIV testing for whom a recent (<12 months) HIV test result is not available. The gene discussed is INS; the disease is diabetes mellitus.