Of all mice models, APPswe/PS1dE9 mice were used in 11 studies, Tg2576 mice and APP/PS1/tau 3 × Tg AD mice were used in 3 studies, SAMP8 mice were used in 2 studies, and Tg-tau mice, NSE/APPsw transgenic mice and ICR mice infused with ibotenic acid were used in other studies. The gene discussed is APP; the disease is Alzheimer disease.