In this study, our results demonstrate that miR-124-3p is an inhibitor of metastasis in NSCLC, and it can bind to the 3’UTR of Rab27a, thereby suppressing the translation process of Rab27a, leading to a reduction in exosome secretion It also inhibits the activation of PI3K/AKT signaling pathway, and either function of miR-124-3p enables the repression of the metastasis in NSCLC. Here, AKT1 is linked to non-small cell lung carcinoma.