NLRP3 and head and neck squamous cell carcinoma: High expression of NLRP3 is also associated with the growth, invasion, and metastasis of HNSCC, with poor clinical prognosis in patients with oral squamous cell carcinoma (OSCC) treated with 5-FU, and NLRP3 gene knockout increases pyroptosis of 5-FU-induced OSCC cells [61, 62].