SPHK1 and diffuse large B-cell lymphoma: Significantly up-regulated expression of SPHK1 was found in DLBCL (n = 55) versus centroblast B-cells from huma tonsils (n = 7), in FL (n = 14) versus normal B-cells (n = 5), and in PTCL-NOS (n = 68) versus normal T cells (n = 10).