MKI67 and neoplasm: In comparison with the EL4-CD mice, the aggressive tumor growth pattern in the EL4-WSHFD mice was evident as the significant increased weight of tumor mass and the advanced stage (Fig. S2 and Fig. 2E), extensive tumor invasion of the draining lymph nodes (LNs), and significantly increased proliferation by Ki-67 staining in the LN tissues which infiltrated with tumor cells (Fig. 2F).