In the tumor tissues of EL4-WSHFD mice, significantly increased protein levels of S1PR1 and S1PR3 by Western blotting were found (Fig. 3F) and the finding was consistent with previous studies in which S1PR1 and S1PR3 were reported as overexpression of the two most important signaling molecules involved in the lymphomagenesis [22, 34]. This evidence concerns the gene S1PR1 and neoplasm.