By dual fluorescent staining, we further investigated the co-expression of F4/80 and 12/15-LOX in the isolated macrophages from EL4-WSHFD mice and found that F4/80 localized mostly on the cell membrane while 12/15-LOX localized mainly in nucleolus, however, 12/15-LOX was not detected in the EL4 lymphoma cells (Fig. 6C), which was consistent to previous report that lymphoma cells did not express ALOX15 [45]. Here, LOX is linked to lymphoma.