Our results agreed with the studies from others, 1) the S1P/S1PR1 axis was suggested for lymphomagenesis in the DLBCL patients [51]; 2) the S1P/S1PR3 axis promoted the nuclear translocation of YAP, which contributed to the formation of the YAP-c-MYC complex [35]; and 3) S1P treatment promoted the proliferation of primary cultured OECs mediated by S1PR1 [52]. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.