Previous studies reported that TLR4 signaling plays a predominant role in the innate immune response of retinal ischemia by promoting the activation of caspase-8 signaling, and inhibition of caspase-8 has no influence on the production of TLR4 in IOP-induced retinal injury, indicating that TLR4 signaling contributes to the caspase-8 activation [28]. The gene discussed is CASP8; the disease is retinal ischemia.