The Food and Drug Administration (FDA) has approved various ICIs for cancer therapy [2], including programmed death-1 (PD-1) receptor inhibitors (e.g., cemiplimab, nivolumab and pembrolizumab), programmed death ligand-1 (PD-L1) inhibitors (e.g., atezolizumab, avelumab and durvalumab), and cytotoxic T lymphocyte-associated antigen (CTLA-4) inhibitors (ipilimumab) [3–5]. The gene discussed is CD274; the disease is cancer.