In the last years, PCa initial staging has been profoundly reshaped by the introduction of [18F]F- or [68 Ga]Ga-labelled radiotracers targeting the Prostate-Specific Membrane Antigen (PSMA) [6, 7], a type II integral membrane glycoprotein encoded by the FOLH1 gene whose expression is markedly higher in PCa than in normal prostatic tissues [8]. Here, FOLH1 is linked to posterior cortical atrophy.