The most common AEs in all cohorts were rash (26/42, 61.9%), increased creatine phosphokinase (CK) (25/42, 59.5%), face edema (21/42, 50.0%), increased AST (20/42, 47.6%), peripheral edema (17/42, 40.5%), diarrhea (14/42, 33.3%), increased ALT (14/42, 33.3%), and paronychia (8/42, 19.0%), most of which were grades 1–2. The gene discussed is GPT; the disease is paronychia.