The Kaplan–Meier survival analysis was performed to investigate the association between AQP4 expression and prognosis of gliomas to describe the Overall Survival (OS) curves of AQP4 over- and lower-expression groups in all gliomas (TCGA GBM and LGG), GBM, and LGG datasets, respectively. This evidence concerns the gene AQP4 and central nervous system cancer.