IFNA1 and Autoimmunity: G3BP1 (GTPase-activating protein SH3 domain-binding protein 1), a RBP important for stress granule assembly,92 enhances DNA binding of cGAS and cGAS-dependent IFN production, which is associated with enhanced intracellular nucleic acid-induced autoimmunity.93 The G3BP1 chemical inhibitor EGCG can specifically inhibit cGAS-related autoinflammation.94 These studies indicate a potential role for RNA- or RBP-dependent activation of cGAS pathway in autoimmunity.