TFRC and Autoimmunity: PTEN upregulation by Roquin inhibits mTOR signaling and suppresses the conversion of Treg to Tfr cells.216 However, it remains unclear how altering the conversion of non-follicular Treg cells to Tfr cells eventually affects the final outcome of autoimmunity, given their respective indispensable role in limiting effector T cells and Tfh cells.