T cell conditional genetic inactivation of WTAP relieves Orai1 and Ripk1 mRNA transcription correlated with T cell activity.208 METTL14 deficiency in T cells also causes spontaneous colitis in mice characterized by increased Th1/Th17 response and impaired Treg cell induction, indicating a role for METTL14 in maintaining Treg cells for protection against colitis.209. The gene discussed is ORAI1; the disease is colitis.