SKIC2 and systemic lupus erythematosus: The super-killer (SKI) complex component SKIV2L, encoding a subunit of the RNA exosome responsible for RNA degradation, is a potential susceptibility gene for human SLE.71 Mutations in the human SKIV2L gene cause tricohepatoenteric syndrome characterized by immunodeficiency, severe diarrhea, skin and hair abnormalities.