MYD88 and Autoimmunity: Alternative splicing is triggered by various stress signals and represents an important RBP-dependent post-transcriptional regulatory mechanism that affects many molecular components of inflammation and autoimmunity, including receptors, adaptors, and proinflammatory cytokines.98 Myeloid differentiation primary response gene 88 (Myd88) encodes an important adaptor protein (MyD88) associated with TLR signaling and is widely implicated in immune pathogenesis and tissue damage of AIDs.