The m6A writer METTL3 is required for antitumor effects of NK cells and positively regulates accumulation, effector function and homeostasis of NK cells in a manner involving m6A modification of SHP2 coding gene.176 Similarly, the m6A reader YTHDF2 maintains homeostasis, maturation, antitumor and antiviral immunity of NK cells, by forming a STAT5-YTHDF2 positive feedback loop.177 More evidences are required to uncover whether m6A methylation in NK cells is associated with autoimmunity and autoinflammation. Here, YTHDF2 is linked to Autoimmunity.