HNRNPA2B1 and systemic lupus erythematosus: We show that the RBP heterogeneous nuclear ribonucleoprotein A2B1 (hnRNP A2B1) can recognize viral DNA to initiate type I IFN production in a TBK1-STING-dependent way as well as enhance cGAS expression and cGAS-initiated IFN production, thus contributing to the antiviral defense.95 hnRNP A2B1 can also recognize host genomic DNA, and autoantibodies against hnRNP-A2 are observed in patients with SLE,96 indicating a potential involvement of hnRNP A2B1 in the development of autoinflammation.