A comparison of kidneys in old and young mice showed that SASP factors contributing to glomerulosclerosis in old mice, such as PAI-1, IL-1β, IL-6, or MMPs80, were upregulated, and PAI-1 expressed by glomerular ECs may mediate crosstalk with podocytes to induce podocyte detachment and apoptosis81. The gene discussed is SERPINE1; the disease is glomerulosclerosis.