In contrast to molecular signatures identified empirically via “omics” to be “differentially expressed,” DNB theory identified the 6th day as the key node between the healthy state and osteoporosis for the first time, moving the triggering phase prior to the drastic transition to the osteoporosis phase forward by 2 days (from 8 dpf to 6 dpf)13,38, and it identified cdkn1a as a core member of DNBs. The gene discussed is CDKN1A; the disease is osteoporosis.