Notably, ADAR1 gene amplification and mutation of the CTNNB1 gene, encoding β-catenin protein B, were mutually exclusive in liver cancer in the TCGA_LIHC dataset, this mutation was found to be most prevalent among all the mutations (38.2%, n = 138) in the 32 cancer types investigated in TCGA Pan-Cancer Atlas, and this mutually exclusive tendency was found only in liver cancer (Fig. 1d and Supplementary Table 2). The gene discussed is ADAR; the disease is cancer.