On the basis of the expression of the newly edited and generated ED_miR-3144(3_A < G) target gene was reduced as liver cancer progressed, five candidates, INMT, GHR, GLYAT, SLC38A4, and HMGCS2, were identified through target prediction and expression pattern analyses (Supplementary Fig. 5c, d; Supplementary Table 3). The gene discussed is HMGCS2; the disease is liver cancer.