This critical ADAR1-dependent change in the canonical miR-3144-3p seed region attenuated the negative regulation of canonical miR-3144-3p activity on MSI2 mRNA and simultaneously created a novel edited mutant of miRNA, ED_miR-3144(3_A < G), which inhibited the mRNA translation of the tumor suppressor SLC38A4 in liver cancer cells. The gene discussed is ADAR; the disease is liver cancer.