IL4R and Alzheimer disease: To understand whether IL-4Rα would be essential in other forms of AD, such as the one induced by acute skin irritants, we compared iLCKcreIL-4Rα−/lox, LCKcreIL-4Rα−/lox, CD4creIL-4Rα−/lox mice to their respective littermate controls (Fig. 2A).