CDC6 and systemic lupus erythematosus: In order to explore the function of CDC6 in human cells and in SLE, we transfected Hela cells or SLE patients' PBMCs with si-CDC6 mRNA, which significantly inhibited the expression of CDC6 in these cells (Fig. 8e) After CDC6 knockdown, the proliferation of Hela cells and PBMCs were prominently impaired compared with si-NC or Control (Fig. 8f).