HMGB1 and early-onset autosomal dominant Alzheimer disease: For example, HMGB1 was identified by proteome analysis of polyglutamine (polyQ) disease19, Ku70 by interactome analysis of Huntington’s disease (HD)20, and MARCKS, SRRM2, HMGB1, and YAP by phosphoproteome analysis of Alzheimer’s disease pathology21–24.