Niroula et al. have argued against this notion in their recent elegant study by analyzing CHIP in 55,385 healthy individuals and subclassifying CHIP mutations into driver mutations associated with lymphoid malignancies, termed lymphoid CHIP (L-CHIP), and driver mutations associated with myeloid malignancies, termed myeloid CHIP (M-CHIP) [17]. Here, STUB1 is linked to myeloid neoplasm.