Our study focused on the expression and function of CCKAR in ASM cells, which are the main effector of bronchoconstriction, but previous studies had reported the expression of CCK receptors in other lung cell types, including bronchial epithelial cells, alveolar epithelial cells, pulmonary macrophages, and pulmonary vascular endothelial cells29,30,32, whose roles in asthma are tightly linked to inflammation. The gene discussed is CCKAR; the disease is asthma.