IL10 and paracoccidioidomycosis: Gonçales et al. [8] emphasized that the overexpression of PCN, owing to its N-acetylglucosaminidase activity, promotes chitin hydrolysis to tiny fragments, responsible for increasing macrophage production of IL-10 and M2-type cell polarization, which are characteristically found in severe and disseminated forms of paracoccidioidomycosis.