APOBEC3B and cancer: For example, A 110 kb gap containing gene UGT2B17 were observed in more than half samples in all groups; A 27 kb gap containing most exons of gene HEATR4 were observed in all three samples from healthy donor group, most samples from cancer group, but only 1/3 samples from benign nodule group; A 29 kb gap containing gene APOBEC3B were observed in some samples from benign nodule and cancer group, but not in healthy donors.