Notably, NF‐κB signaling determines the sensitivity to T‐cell AICD[19] and is shown to be a downstream target of lactic acid.[20] Indeed, decreased NF‐κB activation was observed in tumor‐specific cytotoxic CD8+ T‐cells from KRAS mutant versus wild‐type CRC (Figure 5I). Here, CD8A is linked to colorectal carcinoma.