Recent research indicated that KRAS mutation was associated with several immune cell types in the tumor microenvironment.[23, 24, 25] This work further reinforced this concept by demonstrating a cell‐extrinsic role of mutant KRAS in crosstalk with cytotoxic CD8+ T‐cell tumor infiltration in the context of CRC progression. This evidence concerns the gene CD8A and colorectal carcinoma.