KRAS and neoplasm: We previously revealed that mutant KRAS‐expressing tumor cell‐derived lactic acid played significant roles in the tumor microenvironment engagement and confirmed that mutant KRAS had the ability to directly drive high‐level lactic acid production.[12] These findings were further verified herein, which showed significantly higher lactic acid concentrations in KRAS mutant versus wild‐type tissues (Figure5A; Figure S4A, Supporting Information).