In absence of AD-typical βAmyloid plaques in ALS, we combined Dkk2 mRNA FISH and microglial immunohistochemical labeling with the immunolabelling of GFAP to visualize astrocytes and immunolabelling of misfolded SOD1 to visualize aggregates of misfolded mutant SOD1G93A. This evidence concerns the gene DKK2 and amyotrophic lateral sclerosis.