DKK2 and Alzheimer disease: To this end, we performed mRNA FISH on coronal brain cryosections to detect Dkk2 mRNA in situ and acquired images from the motor cortex and the stratum pyramidale, with adjacent stratum oriens and stratum radiatum, of the hippocampal CA1 region, which are brain regions burdened by βAmyloid plaques, neurofibrillary tangles and neuronal degeneration in AD patients and animal models.