Thus, we were able to largely replicate our findings regarding microgliosis and microglial Dkk2 upregulation in two widely used AD mouse models (APPNL-G-F and APP/PS1 mice), again adding spatial information to a previously published meta-analysis of single-cell RNA-Seq datasets (Friedman et al., 2018). Here, DKK2 is linked to Alzheimer disease.