In absence of AD-typical βAmyloid plaques in ALS, we combined Dkk2 mRNA FISH and microglial immunohistochemical labeling with the immunolabelling of GFAP to visualize astrocytes and immunolabelling of misfolded SOD1 to visualize aggregates of misfolded mutant SOD1G93A. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.