Having demonstrated microgliosis and clustering of Dkk2+ microglia around βAmyloid plaques in two different widely used AD mouse models, we next investigated whether our findings could be recapitulated in another neurodegeneration mouse model, the SOD1G93A amyotrophic lateral sclerosis (ALS) mouse (Gurney et al., 1994). The gene discussed is DKK2; the disease is Alzheimer disease.