Crucially however, we added valuable spatial information on the location of Dkk2+ microglia with respect to neurodegenerative lesions such as βAmyloid plaques in AD mouse models, where Dkk2+ microglia exhibited a potential to cluster near βAmyloid plaques that was greater or at least equal to that of Dkk2– microglia, at least in advanced-APPNL-G-F mice. The gene discussed is DKK2; the disease is Alzheimer disease.