TFAP2E and gastric cancer: SAHA‐CDDP‐coupled supramolecular conjugates self‐assembled into nanomicelles, which preferentially accumulated in tumor sites through the EPR effect and further showed remarkable therapeutic efficacy on cisplatin‐resistant NSCLC tumors.[103] The low sensitivity of most patients with advanced gastric cancer to 5‐fluorouridine (5‐FU) can be attributed to the hypermethylation of transcription factor AP‐2 epsilon (TFAP2E).