The mannosylated lactoferrin nanoparticles (Man‐LF‐SHK/JQ1 NPs) were prepared for delivering shikonin (a naphthoquinone pigment isolated from the traditional Chinese herb Zicao) and JQ1 (a PD‐1 blockage agent) to cancer cells and TAMs via mannose receptor (MR) and LRP1. This evidence concerns the gene PDCD1 and cancer.