The infiltration of TAMs was increased in breast cancer tissue, which was attributed to the fact that EZH2‐mediated epigenetic silencing of miR‐29b or miR‐30d promoted the expression of lysyl oxidase 4, which especially drove the tumorigenesis and metastasis of breast cancer cells through TAM2 activation and collagen remodeling.[61] The histone demethylase JMJD1A (JHDM2A, KDM3A) drove tumor aggressiveness by promoting angiogenesis and TAM infiltration into tumor tissue under hypoxia and nutrient starvation. This evidence concerns the gene ORAI1 and neoplasm.