TAM infiltration into tumor tissue contributed to lymphangiogenesis and lymphatic metastasis by producing vascular endothelial growth factor C (VEGF‐C), a class of lymphangiogenesis growth factors.[58] In addition, the drug resistance mechanism of tumors is associated with CCL2‐mediated macrophage remodeling involving epigenetic alteration. The gene discussed is CCL2; the disease is neoplasm.