PLGA‐poly(ethylene glycol) (PEG) diblock conjugated 5‐AZA nanomicelles (AZA‐PLGA‐PEG) were designed, with the characteristics of excellent stability, enhanced intratumor release, high bioavailability, and enhanced anti‐breast cancer cell proliferation.[96] Euchromatic histone‐lysine N‐methyltransferase 2 (EHMT2) predominantly transfers methyl from SAM to H3K9 to induce H3K9me1 and H3K9me2; and is thus, considered a potential therapeutic target for hepatocellular carcinoma (HCC). The gene discussed is EHMT2; the disease is hepatocellular carcinoma.