miR‐138‐5p integrated into TAMs downregulated lysine demethylase 6B (KDM6B or JMJD3) expression, which elicited the enrichment of H3K27me3 in the promoter region encoding pro‐inflammatory genes; consequently resulting in the inhibition of TAM1, the activation of TAM2, and promoting the lung metastasis of breast cancer.[60]. The gene discussed is ORAI1; the disease is breast carcinoma.