The Man‐LF‐SHK/JQ1 NPs had the antitumor ability to reshape the tumor immune microenvironment via the repression of glucose metabolism, repolarization of TAMs, initiation of ICD, and JQ1‐mediated PD‐1 blockage.[55] SAHA‐mediated inhibition of HDAC2 may be associated with the repolarization of TAM2 to TAM1, which could overcome drug resistance in EGFR‐TKI therapy. Here, PDCD1 is linked to neoplasm.