After passively accumulating AOZNs in tumor tissue through the EPR effect, Orz and AMPCP were released from nanomicelles in response to GSH in the TME, and then, synergistically induced GSDMD‐mediated pyroptosis in tumor cells and alleviated the TIME through the promotion of T‐cell infiltration and DC maturation and the suppression of immunosuppressive MDSC accumulation and TAM2 polarization. This evidence concerns the gene GSDMD and neoplasm.