Apart from the combination of epigenetic agents and molecularly targeted drugs, the PHPNJ NP‐activated antitumor immune response symphysis with photodynamic therapy (PDT)‐triggered immunogenic cell death (ICD) of tumor cells showed significant anti‐colon and breast cancer effects.[118] DNMTi‐induced PD‐L1 expression resensitized tumors to PD‐L1 checkpoint blockade therapy. This evidence concerns the gene CD274 and neoplasm.