ADT includes the induction of hypogonadism through orchiectomy and a luteinizing hormone-releasing hormone (LH-RH) agonist, alone or combined with an androgen blockade (LH-RH agonist plus antiandrogen) [4,5] However, ADT decreases androgen activity, causing lower estrogen. The gene discussed is GNRH1; the disease is hypogonadism.