As EGF receptor, Vav1, RhoA, Rac1, and BPGAP1 are all associated with oncogenesis and/or cancer metastasis, the identification of this novel EGFR-BPGAP1-Vav1-Rac1-RhoA signaling axis could provide new approaches to a combinatorial therapeutic intervention in cancer progression. This evidence concerns the gene ARHGAP8 and cancer.