Gene markers for the mesenchymal subtypes indicate less heterogeneity than the epithelial clusters, characterized by shared expression of multiple genes across the cell clusters, including COL1A1, COL1A2, and TAGLN. Top gene hits for each primary tumor dataset cluster are leveraged to perform functional network predictions for each subpopulation, illustrated by the cnet plots in Supplementary Fig. 2. The gene discussed is COL1A1; the disease is neoplasm.