Then, using IMC and a 33-antibody panel, they identified 51 cell clusters (including 30 immune cell clusters and 14 tumor cell clusters) and specific spatial features that characterize IR + tumors (co-localization of resident CD8+ T cells and DC) and IR − tumors (interactions between lymphocytes and immunosuppressive myeloid cells) [61]. Here, CD8A is linked to neoplasm.