ARL3 and retinal degeneration: Both a rod-specific Arl3 knockout mouse or a transgenic mouse overexpressing constitutively active Arl3-Q71L in rods show severe retinal degeneration by 2 months and result in measurable effects on lipidated protein delivery to the outer segment (Hanke-Gogokhia et al., 2016; Wright et al., 2016).