SGCB and pulmonary arterial hypertension: In the present study, we investigated the effects of β3 AR stimulation on pulmonary hemodynamics, right ventricular (RV)–pulmonary artery (PA) coupling efficiency, and compared the putative efficacy of β3 AR stimulation to guideline‐recommended agents that potentiate the downstream sGC‐cGMP pathway in two experimental models of PAH.