Then, western blotting assay also demonstrated that the enhanced PARP1 cleavage in circTFDP2 knockdown PCa cells was blocked by Z‐DEVD‐FMK, a caspase‐3 inhibitor, suggesting that circTFDP2 prevented PARP1 from active caspase‐3‐dependent cleavage (Figure 5I). The gene discussed is PARP1; the disease is posterior cortical atrophy.