AGO2 and small cell lung carcinoma: Given that most miRNAs exist with AGO2 protein forming a RNA-induced silencing complex (RISC) and exosomes [21, 29, 30], we performed a gold nanoprobe-mediated in situ (RNA isolation free) detection of miR-1 in the serum samples of human SCLC patients and healthy donors (Fig. 1F, supplementary Fig. S3-S4).