CXCL12 and small cell lung carcinoma: In addition, the FOXM1 ChIP analysis in the presence of CXCL12 (CXCR4 ligand) and miR-1 knockdown suggested enhanced FOXM1 binding to the promoter region of RRM2, further supporting CXCR4-mediated modulation of FOXM1-RRM2 interactions in SCLC.