Altogether, the CXCR4 cell surface expression analysis (Fig. 5F), 3'-UTR targeting, and FOXM1-RRM2 ChIP-qPCR experiments demonstrate that miR-1 targets CXCR4 and significantly decreases the accessibility of FOXM1 to RRM2-promoter (transcriptionally decreased RRM2), implying that miR-1 targets the CXCR4/FOXM1-RRM2 axis in SCLC. This evidence concerns the gene RRM2 and small cell lung carcinoma.