RRM2 and small cell lung carcinoma: Consistent with the previous studies that showed FOXM1 is regulated in a p53 and Rb/E2F dependent manner, our data suggest that miR-1 overexpression downregulated SCLC specific gene signatures such as CXCR4, FOXM1, PLK1, CENPA, AURKA/B, and RRM2 [57, 59, 60], while miR-1 inactivation increased their expression.