Therefore, using a model of myocardial injury in type 2 diabetic mellitus (T2DM) rats, the aim of this study was to investigate the potential effect of OMT on myocardial injury and elucidate the role of the Nrf2/HO-1 and JAK2/STAT3 signaling pathways in diabetic rats. Here, STAT3 is linked to diabetes mellitus.