The sensitivity of Tim-3, NT proBNP, and sestrin2 in diagnosing the left-to-right shunt congenital heart disease with heart failure was 58.3, 58.3, 83.3%, respectively, and the specificity was 85.0, 72.5, 70.0%, respectively, shown in Table 5. This evidence concerns the gene HAVCR2 and congenital heart disease.