ROC curve analysis showed that the AUCs of Tim-3, NT proBNP, and sestrin2 in diagnosingthe left-to-right shunt congenital heart disease combined with heart failure were 0.744 (95% CI 0.580–0.908), 0.608 (95% CI 0.359–0.857), 0.744 (95% CI 0.592–0.896), respectively (Fig. 1). Here, NPPB is linked to congenital heart disease.