P2RX7 and migraine disorder: Consistent with the view that ATP, acting via P2X7 receptors, can trigger pro-inflammatory processes activating dural immune cells [27, 83, 84], we have observed that the P2X7-preferring agonist BzATP enhances release of the pro-inflammatory tumor necrosis factor-α (TNFα) and of the anti-inflammatory cytokine Il-10, both implicated in migraine pain [90, 91].