TP53 and colonic neoplasm: Moreover, various p53 target drugs are under clinical trial PRIMA-1MET (APR-246; NCT03745716; Phase III) has a p53-independent inhibitory activity in the colon cancer cell, and the mechanism of antitumor activity of the mutp53 reactivator COTI-2 (NCT02433626; Phase I) is still not comprehensively understood in many cancers, including colon cancer [15].