Demographic data (age and sex) and histopathological parameters (Biopsy type, histological type of tumour, grade, presence or absence of lymphovascular invasion (LVI) and perineural invasion (PNI), presence or absence of carcinoma in-situ (CIS) and type of CIS, hormone receptor (ER, PR) status, HER-2 expression, Ki-67 score, size of tumour and nodal involvement) in both males and females are presented in Table 1. This evidence concerns the gene MKI67 and in situ carcinoma.