We computed the average R2 by gene, detecting eight genes in the AD group with R2 > 0.10 (NAPRT1, PAX8, OR2L13, NLRP2, TMEM173, DNAJC15, PDPR, and CES1), and almost the same genes in ND (NAPRT1, NLRP2, OR2L13, KLHDC8B, PAX8, TSTD1, PPM1M, CES1, and EFHB). Here, CES1 is linked to Alzheimer disease.