However, in the AD scRNA study from Mathys et al. (2019) (dorsolateral prefrontal cortex), ANK1 was not detected in microglia and was significantly downregulated only in excitatory neurons in the individual model (log2 FC =  − 0.248; adj p = 1.1E-18), but not in the mixed model. This evidence concerns the gene ANK1 and Alzheimer disease.